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Diabetes News

Category: Pathology


Joint 30-year HbA1c and lipid trajectories and mortality in type 1 diabetes

February 18th 2022

These results suggest there is a subgroup with type 1 diabetes who, despite poor glycemic control, has a relatively good prognosis, perhaps related to good Non-HDLc (Diabetes Research and Clinical Practice)

Categories: News, Pathology
Tags: glycaemic control, HbA1c, lipid, Type 1 Diabetes

Categories: Pathology
Tags: glycaemic control, HbA1c, lipid, Type 1 Diabetes

The gut hormone glucose-dependent insulinotropic polypeptide is downregulated in response to myocardial injury

February 6th 2022

Circulating GIP levels are downregulated in patients with myocardial infarction and following cardiac surgery. These results might suggest nutrition-independent regulation of GIP secretion following myocardial injury in humans (Cardiovascular Diabetology)

Categories: Cardiovascular, News, Pathology

Categories: Cardiovascular, Pathology

Changes of insulin resistance status and development of complications in type 1 diabetes mellitus: Analysis of DCCT/EDIC study

January 23rd 2022

This study highlights the importance of IR changes represented by eGDR in the development of diabetic complications. Patients with T1D and IR may require intensive therapy (Diabetes Research and Clinical Practice)

Categories: News, Pathology
Tags: Insulin resistance, Type 1 Diabetes

Categories: Pathology
Tags: Insulin resistance, Type 1 Diabetes

Glycemic Control and Risk of Sepsis and Subsequent Mortality in Type 2 Diabetes

January 20th 2022

In a nationwide cohort of individuals with type 2 diabetes, we found a U-shaped association between HbA1c and sepsis and a fourfold increased risk of death among those developing sepsis (Diabetes Care)

Categories: News, Pathology
Tags: HbA1c, Sepsis, Type 2 Diabetes

Categories: Pathology
Tags: HbA1c, Sepsis, Type 2 Diabetes

Prediabetes and risk of mortality, diabetes-related complications and comorbidities: umbrella review of meta-analyses of prospective studies

January 18th 2022

Prediabetes was positively associated with risk of all-cause mortality and the incidence of cardiovascular outcomes, CHD, stroke, chronic kidney disease, cancer and dementia (Diabetologia)

Categories: Cardiovascular, Nephropathy, News, Pathology
Tags: prediabetes

Categories: Cardiovascular, Nephropathy, Pathology
Tags: prediabetes

Relative leucocyte telomere length is associated with incident end-stage kidney disease and rapid decline of kidney function in type 2 diabetes: analysis from the Hong Kong Diabetes Register

January 18th 2022

rLTL is independently associated with incident ESKD and rapid eGFR loss in individuals with type 2 diabetes. Telomere length may be a useful biomarker for the progression of kidney function and ESKD in type 2 diabetes (Diabetologia)

Categories: News, Pathology
Tags: leucocyte telomere, Type 2 Diabetes

Categories: Pathology
Tags: leucocyte telomere, Type 2 Diabetes

Elevated serum uric acid is a facilitating mechanism for insulin resistance mediated accumulation of visceral adipose tissue

January 12th 2022

Elevated SUA acts as a mediator inside the bidirectional relationship between IR and VAT accumulation and these observations could be applicable at a phenotype scale (Clinical Endocrinology)

Categories: News, Pathology
Tags: Insulin resistance, uric acid

Categories: Pathology
Tags: Insulin resistance, uric acid

The many faces of diabetes. Is there a need for re-classification? A narrative review

January 9th 2022

This review aims to examine the physiological mechanisms in diabetes, risks for complications, the effects of bariatric and metabolic surgery and will shed light on whether diabetes should be reclassified (BMC Endocrine Disorders)

Categories: News, Pathology
Tags: complications

Categories: Pathology
Tags: complications

Bempedoic acid in patients with type 2 diabetes mellitus, prediabetes, and normoglycaemia

January 6th 2022

Bempedoic acid significantly lowered LDL-C across glycaemic strata and did not worsen glycaemic parameters nor increase incidence of new-onset diabetes vs placebo over a median follow-up of 1 year (Diabetes, Obesity and Metabolism)

Categories: News, Pathology
Tags: bempedoic acid, Type 2 Diabetes

Categories: Pathology
Tags: bempedoic acid, Type 2 Diabetes

Elevated liver enzymes and comorbidities in type 2 diabetes: A multicentre analysis of 51 645 patients from the Diabetes Prospective Follow-up (DPV) database

January 5th 2022

Elevated liver enzymes are common in patients with T2D and clearly correlate with a higher prevalence of clinically relevant comorbidities. Assessing liver enzymes should be standard clinical routine in T2D due to a possible predictive role for comorbidities and complications (Diabetes, Obesity and Metabolism)

Categories: Hepatology, News, Pathology
Tags: comorbidities, liver enzymes, Type 2 Diabetes

Categories: Hepatology, Pathology
Tags: comorbidities, liver enzymes, Type 2 Diabetes

A novel diabetes typology: towards precision diabetology from pathogenesis to treatment

January 4th 2022

This review discusses evidence from recent studies addressing the complexity of diabetes by proposing novel subgroups (subtypes) of diabetes (Diabetologia)

Categories: News, Pathology
Tags: subgroups

Categories: Pathology
Tags: subgroups

The Role of Glucagon in Glycemic Variability in Type 1 Diabetes: A Narrative Review

December 20th 2021

There is growing evidences to illustrate the contribution of glucagon secretion to the glycemic variability in patients with T1DM, which may promote the development of new treatment strategies aiming to mitigate glycemic variability associated with aberrant glucagon secretion (Metabolic Syndrome and Obesity)

Categories: News, Pathology, Treatment
Tags: glucagon, glycemic variability, Type 1 Diabetes

Categories: Pathology, Treatment
Tags: glucagon, glycemic variability, Type 1 Diabetes

Association of thyroid hormone with body fat content and lipid metabolism in euthyroid male patients with type 2 diabetes mellitus: a cross-sectional study

December 9th 2021

This study found that the changes in thyroid hormones are associated with various body fat content and lipid metabolism in euthyroid male patients with T2DM (BMC Endocrine Disorders)

Categories: News, Pathology
Tags: thyroid

Categories: Pathology
Tags: thyroid

Associations between serum total bilirubin, obesity and type 2 diabetes

December 8th 2021

This study suggests that STB is associated with an elevated risk of T2D. More importantly, we reported for the first time that BMI may moderate the association between bilirubin and T2D (Diabetology & Metabolic Syndrome)

Categories: News, Obesity, Pathology
Tags: bilirubin, Type 2 Diabetes

Categories: Obesity, Pathology
Tags: bilirubin, Type 2 Diabetes

Impact of COVID-19 Vaccination on Glycemia in Individuals With Type 1 and Type 2 Diabetes: Substudy of the COVAC-DM Study

December 1st 2021

Our data revealed that COVID-19 vaccination per se did not change glycemic control in people with diabetes. Of note, on days on which side effects were present, a deterioration of glycemia was observed in people with type 1 diabetes (Diabetes Care)

Categories: News, Pathology
Tags: COVID-19, Type 1 Diabetes, Type 2 Diabetes

Categories: Pathology
Tags: COVID-19, Type 1 Diabetes, Type 2 Diabetes

Classic Type 1 Diabetes Mellitus and Fulminant Type 1 Diabetes Mellitus: Similarity and Discrepancy of Immunological Characteristics and Cytokine Profile

November 29th 2021

Compared with T1ADM, CRP and leukocytes’ levels were increased significantly in FT1DM, with an increase in neutrophil% and decline in lymphocyte%, suggesting that FT1DM may have more abrupt onset and occur as a more serious subtype of type 1 diabetes mellitus (Diabetes, Metabolic Syndrome and Obesity)

Categories: News, Pathology
Tags: fulminant, Type 1 Diabetes

Categories: Pathology
Tags: fulminant, Type 1 Diabetes

Gut Microbiome Activity Contributes to Prediction of Individual Variation in Glycemic Response in Adults

November 20th 2021

We demonstrate for the first time that metatranscriptomic activity of the gut microbiome is correlated with PPGR among adults (Diabetes Therapy)

Categories: News, Pathology
Tags: gut microbiome, metatranscriptomic

Categories: Pathology
Tags: gut microbiome, metatranscriptomic

Adiponectin gene polymorphisms and risk of type 2 diabetes: an updated evidence for meta-analysis

November 18th 2021

Collectively, our findings demonstrated a positive association between ADIPOQ + 276 G > T polymorphism with increased risk of T2D in male individuals with European ethnicity (Diabetology & Metabolic Syndrome)

Categories: Biochemistry, Genetics, News, Pathology
Tags: adiponectin, Type 2 Diabetes

Categories: Biochemistry, Genetics, Pathology
Tags: adiponectin, Type 2 Diabetes

Causal variants in Maturity Onset Diabetes of the Young (MODY) – A systematic review

November 12th 2021

We expect that this paper will help clinicians interpret MODY genetics results with greater confidence. Discrepancies in certain middle-eastern countries need to be investigated as other genes or factors, like consanguinity may be involved in developing diabetes (BMC Endocrine Disorders)

Categories: News, Pathology
Tags: MODY

Categories: Pathology
Tags: MODY

A higher non-severe hypoglycaemia rate is associated with an increased risk of subsequent severe hypoglycaemia and major adverse cardiovascular events in individuals with type 2 diabetes in the LEADER study

November 10th 2021

The analysis of data from the LEADER trial demonstrated that higher rates of NSHEs were associated with both a higher risk of severe hypoglycaemia and adverse cardiovascular outcomes in individuals with type 2 diabetes (Diabetologia)

Categories: Cardiovascular, Medication, News, Pathology
Tags: hypoglycemia, LEADER, Type 2 Diabetes

Categories: Cardiovascular, Medication, Pathology
Tags: hypoglycemia, LEADER, Type 2 Diabetes
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