HHS/DKA occurred mostly in T1D and younger patients. However, both also occurred in T2D, which is of great importance in the treatment of diabetes. Better education programmes are necessary to prevent decompensation and comorbidities (Acta Diabetologica)
Diabetes News
Category: Pathology
Pathophysiology and Management of Type 2 Diabetes Mellitus Bone Fragility
The purpose of this review is to summarize the literature evidence that faces the pathophysiological mechanisms underlying bone fragility in T2DM patients (Journal of Diabetes Research)
Is HDL cholesterol protective in patients with type 2 diabetes? A retrospective population-based cohort study
Our results corroborate the hypothesis that HDL cholesterol levels are nonprotective in T2DM patients. The U-shaped association between HDL-cholesterol levels and mortality associated with infectious diseases should be verified by further studies (Journal of Translational Medicine)
Prevalence of mild cognitive impairment in type 2 diabetes mellitus is associated with serum galectin‐3 level
Gal3 might be associated with cognitive impairment in type 2 diabetes mellitus, and serum Gal3 level might be a new risk factor of MCI in type 2 diabetes mellitus patients (Journal of Diabetes Investigation)
Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes
Glucose controls glucagon secretion by intrinsic and paracrine mechanisms, but their relative significance is still debated52, and secretory defects in type-2 diabetes are not well understood. The current work is first in using high-resolution microscopy to study glucagon secretion both in intact islets and in single dispersed α-cells of healthy and type-2 diabetic donors, thus isolating intrinsic from paracrine mechanisms while having full control over paracrine signaling (Nature Communications )
Circulating Retinol Binding Protein 4 Is Inversely Associated With Pancreatic β-Cell Function Across the Spectrum of Glycemia
Circulating RBP4 levels are inversely and independently correlated with β-cell function across the spectrum of glycemia, providing another possible explanation of the linkage between RBP4 and the pathogenesis of type 2 diabetes (Diabetes Care)
Episodes of severe hypoglycemia is associated with a progressive increase in hemoglobin A1c in children and adolescents with type 1 diabetes
Severe hypoglycemia was followed by a progressive and lasting increase in HbA1c among Danish children and adolescents with T1D. Thus, in addition to the known risk of new episodes of hypoglycemia and cognitive impairment, SH contributes to long‐term diabetes complications (Pediatric Diabetes)
Associations of iron markers with type 2 diabetes mellitus and metabolic syndrome
Our results suggest a link between ferritin and T2DM and MetS, which might be partially explained by hepatic dysfunction (Diabetes Research and Clinical Practice)
Metformin Usage Index and assessment of vitamin B12 deficiency among metformin and non-metformin users with type 2 diabetes mellitus
The MUI can be employed as a risk assessment tool for evaluation of vitamin B12 deficiency in patients with T2D. Further prospective studies are required to determine the MUI thresholds in populations with good nutritional statuses and low prevalence of vitamin B12 deficiency (Acta Diabetologica)
Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China
Patients with previous cardiovascular metabolic diseases may face a greater risk of developing into the severe condition and the comorbidities can also greatly affect the prognosis of the COVID-19. On the other hand, COVID-19 can, in turn, aggravate the damage to the heart (Clinical Research in Cardiology)
Prognostic Significance of Long-term HbA1c Variability for All-Cause Mortality in the ACCORD Trial
Long-term visit-to-visit HbA1c variability was a strong predictor of all-cause mortality. HbA1c VIM combined with HbA1c mean conferred an increased risk for all-cause mortality in the intensive-therapy group (Diabetes Care)
Exocrine Pancreatic Insufficiency in Type 1 and Type 2 Diabetes
Exocrine pancreatic insufficiency is a clinically relevant, frequent but poorly understood disorder in both type 1 and type 2 diabetes (Current Diabetes Reports)
Regression from prediabetes to normal glucose levels is more frequent than progression towards diabetes: The CRONICAS Cohort Study
Regression from pre-diabetes back to euglycemia was much more common than progression to diabetes (Diabetes Research and Clinical Practice)
Iron metabolism and type 2 diabetes mellitus: A meta‐analysis and systematic review
The elevated serum ferritin was one of the risk factors for type 2 diabetes, and soluble transferrin receptor‐to‐ferritin ratio was inversely related to the risk of type 2 diabetes. A systematic review showed that serum transferrin and hepcidin might be directly or indirectly related to the development of diabetes (Journal of Diabetes Investigation)
Analysing the Clinical Features of Pneumomediastinum Associated with Diabetic Ketoacidosis in 79 Cases
Pneumomediastinum associated with DKA is a rare disease, and it has a benign course when an early diagnosis is made and aetiological treatment is administered (Metabolic Syndrome and Obesity: Targets and Therapy )
Progression of Insulin Resistance: A Link between Risk Factors and the Incidence of Diabetes
Change of IR can be used as a surrogate marker of incident diabetes. The progression of IR is an important pathophysiologic link between risk factors and the incidence of diabetes (Diabetes Research and Clinical Practice)
Daytime variability of postprandial glucose tolerance and pancreatic beta‐cell function using 12 hour profiles in persons with type 2 diabetes
There appears to be a shift in diurnal variation in glucose homeostasis and pancreatic beta‐cell function. Subjects had decreased glucose tolerance in response to the first and third meal of the day irrespective of glycaemic control. The variability in glucose tolerance was reflected by both quantitative and qualitative dysfunction of the pancreatic beta‐cell (Diabetic Medicine)
Effects of Gender-Affirming Hormone Therapy on Insulin Sensitivity and Incretin Responses in Transgender People
In this cohort of transgender persons, insulin sensitivity but also post-OGTT incretin responses tend to increase with masculinization and to decrease with feminization (Diabetes Care)
Microvascular complications burden (nephropathy, retinopathy and peripheral polyneuropathy) affects risk of major vascular events and all-cause mortality in type 1 diabetes
The presence and number of microvascular complications should be considered in stratifying overall cardiovascular risk in type 1 diabetes (Cardiovascular Diabetology)
The increased risk of microvascular complications in South Asians with type 1 diabetes is influenced by migration: results from the UK–India multi‐ethnic migration study
In this hypothesis‐generating study, we report that South Asian ethnicity is associated with greater risk of diabetic kidney disease and retinopathy, and lower risk of neuropathy than white European ethnicity (Diabetic Medicine)
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