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Diabetes News

Category: Pathology


Obesity is Associated with Increased Basal and Postprandial β-Cell Insulin Secretion Even in the Absence of Insulin Resistance

July 11th 2020

These results demonstrate that increased insulin secretion in people with obesity is associated with excess adiposity itself and is not simply a compensatory response to insulin resistance (Diabetes)

Categories: News, Pathology
Tags: Insulin resistance

Categories: Pathology
Tags: Insulin resistance

Fasting blood glucose at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes

July 10th 2020

FBG ≥7.0 mmol/l at admission is an independent predictor for 28-day mortality in patients with COVID-19 without previous diagnosis of diabetes (Diabetologia)

Categories: News, Pathology
Tags: COVID-19, FBG

Categories: Pathology
Tags: COVID-19, FBG

Clinical Characteristics and Outcomes of Patients With Diabetes and COVID-19 in Association With Glucose-Lowering Medication

June 22nd 2020

C-reactive protein may help to identify patients with diabetes who are at greater risk of dying during hospitalization. Older patients with diabetes were prone to death related to COVID-19. Attention needs to be paid to patients with diabetes and COVID-19 who use insulin. ACEI/ARB use showed no significant impact on patients with diabetes and hypertension who have COVID-19 (Diabetes Care)

Categories: News, Pathology
Tags: COVID-19, insulin, Type 2 Diabetes

Categories: Pathology
Tags: COVID-19, insulin, Type 2 Diabetes

Early Metabolic Features of Genetic Liability to Type 2 Diabetes: Cohort Study With Repeated Metabolomics Across Early Life

June 22nd 2020

Our results support perturbed HDL lipid metabolism as one of the earliest features of type 2 diabetes liability, alongside higher branched-chain amino acid and inflammatory levels. Several features are apparent in childhood as early as age 8 years, decades before the clinical onset of disease (Diabetes Care)

Categories: News, Pathology
Tags: Type 2 Diabetes

Categories: Pathology
Tags: Type 2 Diabetes

The impact of diabetes on COVID-19 infection

June 10th 2020

Not unexpectedly, dia­betes has been identified as posing a particular adverse risk, along with chronic renal and coronary heart disease, and such surrogate risk indicators as obesity and hypertension (Practical Diabetes)

Categories: News, Pathology
Tags: COVID-19

Categories: Pathology
Tags: COVID-19

COVID-19: is there a link between the course of infection and pharmacological agents in diabetes?

June 3rd 2020

This short review is focused on some open questions emerging from the effort to fully understand the link between COVID-19 and diabetes, mainly in the context of possible harmful or beneficial effects of commonly used drugs in patients with diabetes on the course of COVID-19 infection (Journal of Endocrinological Investigation)

Categories: News, Pathology
Tags: COVID-19

Categories: Pathology
Tags: COVID-19

Multicentre analysis of hyperglycaemic hyperosmolar state and diabetic ketoacidosis in type 1 and type 2 diabetes

June 3rd 2020

HHS/DKA occurred mostly in T1D and younger patients. However, both also occurred in T2D, which is of great importance in the treatment of diabetes. Better education programmes are necessary to prevent decompensation and comorbidities (Acta Diabetologica)

Categories: News, Pathology
Tags: hyperglycemia, hyperosmolar state, Type 1 Diabetes, Type 2 Diabetes

Categories: Pathology
Tags: hyperglycemia, hyperosmolar state, Type 1 Diabetes, Type 2 Diabetes

Pathophysiology and Management of Type 2 Diabetes Mellitus Bone Fragility

May 24th 2020

The purpose of this review is to summarize the literature evidence that faces the pathophysiological mechanisms underlying bone fragility in T2DM patients (Journal of Diabetes Research)

Categories: News, Pathology
Tags: bone, bone fragility, Type 2 Diabetes

Categories: Pathology
Tags: bone, bone fragility, Type 2 Diabetes

Is HDL cholesterol protective in patients with type 2 diabetes? A retrospective population-based cohort study

May 12th 2020

Our results corroborate the hypothesis that HDL cholesterol levels are nonprotective in T2DM patients. The U-shaped association between HDL-cholesterol levels and mortality associated with infectious diseases should be verified by further studies (Journal of Translational Medicine)

Categories: News, Pathology
Tags: HDL, Type 2 Diabetes

Categories: Pathology
Tags: HDL, Type 2 Diabetes

Prevalence of mild cognitive impairment in type 2 diabetes mellitus is associated with serum galectin‐3 level

May 1st 2020

Gal3 might be associated with cognitive impairment in type 2 diabetes mellitus, and serum Gal3 level might be a new risk factor of MCI in type 2 diabetes mellitus patients (Journal of Diabetes Investigation)

Categories: News, Pathology
Tags: Gal3, Type 2 Diabetes

Categories: Pathology
Tags: Gal3, Type 2 Diabetes

Paracrine control of α-cell glucagon exocytosis is compromised in human type-2 diabetes

April 24th 2020

Glucose controls glucagon secretion by intrinsic and paracrine mechanisms, but their relative significance is still debated52, and secretory defects in type-2 diabetes are not well understood. The current work is first in using high-resolution microscopy to study glucagon secretion both in intact islets and in single dispersed α-cells of healthy and type-2 diabetic donors, thus isolating intrinsic from paracrine mechanisms while having full control over paracrine signaling (Nature Communications )

Categories: News, Pathology
Tags: paracrine, Type 2 Diabetes

Categories: Pathology
Tags: paracrine, Type 2 Diabetes

Circulating Retinol Binding Protein 4 Is Inversely Associated With Pancreatic β-Cell Function Across the Spectrum of Glycemia

April 21st 2020

Circulating RBP4 levels are inversely and independently correlated with β-cell function across the spectrum of glycemia, providing another possible explanation of the linkage between RBP4 and the pathogenesis of type 2 diabetes (Diabetes Care)

Categories: News, Pathology
Tags: β-cell function

Categories: Pathology
Tags: β-cell function

Episodes of severe hypoglycemia is associated with a progressive increase in hemoglobin A1c in children and adolescents with type 1 diabetes

April 19th 2020

Severe hypoglycemia was followed by a progressive and lasting increase in HbA1c among Danish children and adolescents with T1D. Thus, in addition to the known risk of new episodes of hypoglycemia and cognitive impairment, SH contributes to long‐term diabetes complications (Pediatric Diabetes)

Categories: News, Pathology
Tags: HbA1c, hypoglycemia, Type 1 Diabetes

Categories: Pathology
Tags: HbA1c, hypoglycemia, Type 1 Diabetes

Associations of iron markers with type 2 diabetes mellitus and metabolic syndrome

April 16th 2020

Our results suggest a link between ferritin and T2DM and MetS, which might be partially explained by hepatic dysfunction (Diabetes Research and Clinical Practice)

Categories: News, Pathology
Tags: ferratin, metabolic syndrome, Type 2 Diabetes

Categories: Pathology
Tags: ferratin, metabolic syndrome, Type 2 Diabetes

Metformin Usage Index and assessment of vitamin B12 deficiency among metformin and non-metformin users with type 2 diabetes mellitus

April 7th 2020

The MUI can be employed as a risk assessment tool for evaluation of vitamin B12 deficiency in patients with T2D. Further prospective studies are required to determine the MUI thresholds in populations with good nutritional statuses and low prevalence of vitamin B12 deficiency (Acta Diabetologica)

Categories: News, Pathology
Tags: B12, metformin, Type 2 Diabetes

Categories: Pathology
Tags: B12, metformin, Type 2 Diabetes

Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China

April 2nd 2020

Patients with previous cardiovascular metabolic diseases may face a greater risk of developing into the severe condition and the comorbidities can also greatly affect the prognosis of the COVID-19. On the other hand, COVID-19 can, in turn, aggravate the damage to the heart (Clinical Research in Cardiology)

Categories: News, Pathology
Tags: COVID-19

Categories: Pathology
Tags: COVID-19

Prognostic Significance of Long-term HbA1c Variability for All-Cause Mortality in the ACCORD Trial

April 2nd 2020

Long-term visit-to-visit HbA1c variability was a strong predictor of all-cause mortality. HbA1c VIM combined with HbA1c mean conferred an increased risk for all-cause mortality in the intensive-therapy group (Diabetes Care)

Categories: Pathology
Tags: ACCORD, HbA1c

Exocrine Pancreatic Insufficiency in Type 1 and Type 2 Diabetes

April 1st 2020

Exocrine pancreatic insufficiency is a clinically relevant, frequent but poorly understood disorder in both type 1 and type 2 diabetes (Current Diabetes Reports)

Categories: News, Pathology
Tags: exocrine, Type 1 Diabetes, Type 2 Diabetes

Categories: Pathology
Tags: exocrine, Type 1 Diabetes, Type 2 Diabetes

Regression from prediabetes to normal glucose levels is more frequent than progression towards diabetes: The CRONICAS Cohort Study

March 22nd 2020

Regression from pre-diabetes back to euglycemia was much more common than progression to diabetes (Diabetes Research and Clinical Practice)

Categories: News, Pathology
Tags: CRONICAS

Categories: Pathology
Tags: CRONICAS

Iron metabolism and type 2 diabetes mellitus: A meta‐analysis and systematic review

March 5th 2020

The elevated serum ferritin was one of the risk factors for type 2 diabetes, and soluble transferrin receptor‐to‐ferritin ratio was inversely related to the risk of type 2 diabetes. A systematic review showed that serum transferrin and hepcidin might be directly or indirectly related to the development of diabetes (Journal of Diabetes Investigation)

Categories: News, Pathology
Tags: ferritin, Type 2 Diabetes

Categories: Pathology
Tags: ferritin, Type 2 Diabetes
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