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Diabetes News

Category: Pathology


Differences in the roles of types 1 and 2 diabetes in the susceptibility to the risk of fracture: a systematic review and meta-analysis

August 17th 2021

This study found that T1DM caused an excess risk to all fractures, including fractures at the hip, upper arm, and ankle than T2DM (Diabetology & Metabolic Syndrome)

Categories: News, Pathology
Tags: fracture, Type 1 Diabetes, Type 2 Diabetes

Categories: Pathology
Tags: fracture, Type 1 Diabetes, Type 2 Diabetes

Long-Term Complications in Youth-Onset Type 2 Diabetes

July 29th 2021

Among participants who had onset of type 2 diabetes in youth, the risk of complications, including microvascular complications, increased steadily over time and affected most participants by the time of young adulthood (NEJM)

Categories: News, Pathology
Tags: Type 2 Diabetes, youth

Categories: Pathology
Tags: Type 2 Diabetes, youth

Adipose Tissue Insulin Resistance Is Longitudinally Associated With Adipose Tissue Dysfunction, Circulating Lipids, and Dysglycemia: The PROMISE Cohort

July 21st 2021

Our findings demonstrate that adipose tissue insulin resistance is prospectively associated with adipose tissue function, HDL, TG, and incident dysglycemia (Diabetes Care)

Categories: News, Pathology
Tags: Insulin resistance, Type 2 Diabetes

Categories: Pathology
Tags: Insulin resistance, Type 2 Diabetes

Mechanisms of reduced peak oxygen consumption in subjects with uncomplicated type 2 diabetes

June 23rd 2021

Effort intolerance and reduced VO2peak is a severe and highly prevalent condition in uncomplicated, otherwise asymptomatic T2D. It results from a major defect in skeletal muscle oxygen extraction coupled with a subtle myocardial systolic dysfunction (Cardiovascular Diabetology)

Categories: News, Pathology
Tags: oxygen, Type 2 Diabetes

Categories: Pathology
Tags: oxygen, Type 2 Diabetes

Estimated insulin sensitivity, cardiovascular risk and hepatic steatosis after 12 years from the onset of T1D

June 3rd 2021

Adiposity, glucose and lipid control over the follow-up are likely to influence both. Enhanced adiposity seems paramount for the onset of hepatic steatosis in T1D patients alike in healthy youths (Diabetes/Metabolism Research and Reviews)

Categories: Cardiovascular, News, Pathology
Tags: hepatic steatosis, insulin sensitivity, Type 1 Diabetes

Categories: Cardiovascular, Pathology
Tags: hepatic steatosis, insulin sensitivity, Type 1 Diabetes

Glycemic Control, Diabetic Complications, and Risk of Dementia in Patients With Diabetes: Results From a Large U.K. Cohort Study

May 26th 2021

Higher or unstable HbA1c levels and the presence of diabetic complications in patients with type 2 diabetes are associated with increased dementia risk. Effective management of glycemia might have a significant role in maintaining cognitive health among older adults with diabetes (Diabetes Care)

Categories: News, Pathology
Tags: dementia

Categories: Pathology
Tags: dementia

Deficits in the Skeletal Muscle Transcriptome and Mitochondrial Coupling in Progressive Diabetes-Induced CKD Relate to Functional Decline

May 15th 2021

Our results indicate that T2DM-induced CKD progression impairs physical function, with implications for altered metabolic transcriptional networks and mitochondrial functional deficits as primary mechanistic factors early in CKD progression in T2DM (Diabetes)

Categories: Nephropathy, News, Pathology
Tags: CKD

Categories: Nephropathy, Pathology
Tags: CKD

Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: The Maastricht Study

May 11th 2021

Our findings show that women with type 2 diabetes are not disproportionately affected by early microvascular complications (Cardiovascular Diabetology)

Categories: News, Pathology
Tags: gender, prediabetes, Type 2 Diabetes

Categories: Pathology
Tags: gender, prediabetes, Type 2 Diabetes

High-dimensional characterization of post-acute sequalae of COVID-19

May 10th 2021

Our high dimensional approach identifies incident sequalae in the respiratory system and several others including nervous system and neurocognitive disorders, mental health disorders, metabolic disorders, cardiovascular disorders, gastrointestinal disorders, malaise, fatigue, musculoskeletal pain, and anemia (Nature)

Categories: News, Pathology
Tags: COVID-19, sequalae

Categories: Pathology
Tags: COVID-19, sequalae

Glycemic and lipid variability for predicting complications and mortality in diabetes mellitus using machine learning

May 5th 2021

Raised variability in HbA1c and lipid parameters are associated with an elevated risk in both diabetic complications and all-cause mortality. The association between hypoglycemic frequency, baseline NLR, and both HbA1c and lipid variability implicate a role for inflammation in mediating adverse outcomes in diabetes, but this should be explored further in future studies (BMC Endocrine Disorders)

Categories: News, Pathology
Tags: HbA1c, hypoglycemia, lipid

Categories: Pathology
Tags: HbA1c, hypoglycemia, lipid

Reduced beta cell number rather than size is a major contributor to beta cell loss in type 2 diabetes

May 3rd 2021

Both beta cell size and number were reduced in participants with type 2 diabetes, with the relative reduction in beta cell number being greater. Decrease in beta cell number appears to be a major contributor to reduced BCM in type 2 diabetes (Diabetologia)

Categories: News, Pathology
Tags: beta cell, Type 2 Diabetes

Categories: Pathology
Tags: beta cell, Type 2 Diabetes

Associations between attainment of incentivized primary care indicators and incident lower limb amputation among those with type 2 diabetes: a population-based historical cohort study

May 1st 2021

Comprehensive primary care-based secondary prevention may offer considerable protection against diabetes-related amputation. This has important implications for diabetes management and medical decision-making for patients, as well as type 2 diabetes quality improvement programs (BMJ Open, Diabetes Research & Care)

Categories: News, Pathology
Tags: amputation, Type 2 Diabetes

Categories: Pathology
Tags: amputation, Type 2 Diabetes

The impact of dusk phenomenon on total glucose exposure in Chinese people with type 2 diabetes

April 22nd 2021

The incidence of dusk phenomenon is about 27.3% in people with type 2 diabetes. The impacts of dusk phenomenon on HbA1c and 24-hour mean glucose were about 0.4% and 0.9 mmol/L and the dusk phenomenon was not related with the dawn phenomenon (Medicine)

Categories: News, Pathology
Tags: HbA1c, Type 2 Diabetes

Categories: Pathology
Tags: HbA1c, Type 2 Diabetes

Glycemic Index, Glycemic Load, and Cardiovascular Disease and Mortality

April 8th 2021

In this study, a diet with a high glycemic index was associated with an increased risk of cardiovascular disease and death (NEJM)

Categories: Cardiovascular, News, Pathology
Tags: glycaemic index, glycaemic load

Categories: Cardiovascular, Pathology
Tags: glycaemic index, glycaemic load

Association of glycemia with insulin sensitivity and β-cell function in adults with early type 2 diabetes on metformin alone

April 7th 2021

Glycemia is strongly associated with β-cell dysfunction in adults with early T2DM treated with metformin alone. Efforts to improve glycemia should focus on interventions aimed at improving β-cell function (Journal of Diabetes and Its Complications)

Categories: News, Pathology
Tags: glycaemic control, metformin, Type 2 Diabetes, β-cell

Categories: Pathology
Tags: glycaemic control, metformin, Type 2 Diabetes, β-cell

Early markers of periodontal disease and altered oral microbiota are associated with glycemic control in children with type 1 diabetes

April 7th 2021

Children with type 1 diabetes showed a continuous relationship between less favorable glycemic control and increased early markers of periodontal disease. Glycemic control was also related to the complexity and richness of the plaque microbiota, with diversity increasing as HbA1c levels increase (Pediatric Diabetes)

Categories: News, Pathology
Tags: periodontal, Type 1 Diabetes

Categories: Pathology
Tags: periodontal, Type 1 Diabetes

Prescription of glucose-lowering therapies and risk of COVID-19 mortality in people with type 2 diabetes: a nationwide observational study in England

March 31st 2021

In the context of the COVID-19 pandemic, there is no clear indication to change prescribing of glucose-lowering drugs in people with type 2 diabetes (Lancet)

Categories: Medication, News, Pathology
Tags: COVID-19, Type 2 Diabetes

Categories: Medication, Pathology
Tags: COVID-19, Type 2 Diabetes

Gut microbiota compositions and metabolic functions in type 2 diabetes differ with glycemic durability to metformin monotherapy

March 5th 2021

There were different compositions of gut microbiota with unique microbial metabolic pathways between type 2 diabetes with and without glycemic durability to metformin monotherapy. Microbial salvage by increasing thiamine biosynthesis might be beneficial for the metformin durable group to maintain optimal glycemic control (Diabetes Research and Clinical Practice)

Categories: News, Pathology
Tags: gut microbiota, metformin, Type 2 Diabetes

Categories: Pathology
Tags: gut microbiota, metformin, Type 2 Diabetes

Trends in predominant causes of death in individuals with and without diabetes in England from 2001 to 2018: an epidemiological analysis of linked primary care records

February 6th 2021

The decline in vascular death rates has been accompanied by a diversification of causes in individuals with diagnosed diabetes and a transition from vascular diseases to cancers as the leading contributor to diabetes-related death. Clinical and preventative approaches must reflect this trend to reduce the excess mortality risk in individuals with diabetes (Lancet Diabetes & Endocrinology)

Categories: News, Pathology
Tags: cancer, mortality

Categories: Pathology
Tags: cancer, mortality

Residual β cell function in long-term type 1 diabetes associates with reduced incidence of hypoglycemia

February 4th 2021

β Cell function can persist in long-duration T1DM. With a peak C-peptide concentration of >0.03 nmol/L, we observed clinically meaningful reductions in the prevalence of severe hypoglycemia (Journal of Clinical Investigation)

Categories: News, Pathology
Tags: hypoglycemia, Type 1 Diabetes, β-cell

Categories: Pathology
Tags: hypoglycemia, Type 1 Diabetes, β-cell
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