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Diabetes News

Category: Pathology


Analysing the Clinical Features of Pneumomediastinum Associated with Diabetic Ketoacidosis in 79 Cases

February 18th 2020

Pneumomediastinum associated with DKA is a rare disease, and it has a benign course when an early diagnosis is made and aetiological treatment is administered (Metabolic Syndrome and Obesity: Targets and Therapy )

Categories: News, Pathology
Tags: DKA, pneumomediastinum

Categories: Pathology
Tags: DKA, pneumomediastinum

Progression of Insulin Resistance: A Link between Risk Factors and the Incidence of Diabetes

February 6th 2020

Change of IR can be used as a surrogate marker of incident diabetes. The progression of IR is an important pathophysiologic link between risk factors and the incidence of diabetes (Diabetes Research and Clinical Practice)

Categories: News, Pathology
Tags: Insulin resistance

Categories: Pathology
Tags: Insulin resistance

Daytime variability of postprandial glucose tolerance and pancreatic beta‐cell function using 12 hour profiles in persons with type 2 diabetes

February 2nd 2020

There appears to be a shift in diurnal variation in glucose homeostasis and pancreatic beta‐cell function. Subjects had decreased glucose tolerance in response to the first and third meal of the day irrespective of glycaemic control. The variability in glucose tolerance was reflected by both quantitative and qualitative dysfunction of the pancreatic beta‐cell (Diabetic Medicine)

Categories: News, Pathology
Tags: Type 2 Diabetes

Categories: Pathology
Tags: Type 2 Diabetes

Effects of Gender-Affirming Hormone Therapy on Insulin Sensitivity and Incretin Responses in Transgender People

November 21st 2019

In this cohort of transgender persons, insulin sensitivity but also post-OGTT incretin responses tend to increase with masculinization and to decrease with feminization (Diabetes Care)

Categories: News, Pathology
Tags: insulin, transgender

Categories: Pathology
Tags: insulin, transgender

Microvascular complications burden (nephropathy, retinopathy and peripheral polyneuropathy) affects risk of major vascular events and all-cause mortality in type 1 diabetes

November 21st 2019

The presence and number of microvascular complications should be considered in stratifying overall cardiovascular risk in type 1 diabetes (Cardiovascular Diabetology)

Categories: News, Pathology
Tags: microvascular

Categories: Pathology
Tags: microvascular

The increased risk of microvascular complications in South Asians with type 1 diabetes is influenced by migration: results from the UK–India multi‐ethnic migration study

November 13th 2019

In this hypothesis‐generating study, we report that South Asian ethnicity is associated with greater risk of diabetic kidney disease and retinopathy, and lower risk of neuropathy than white European ethnicity (Diabetic Medicine)

Categories: News, Pathology
Tags: South Asian, Type 1 Diabetes

Categories: Pathology
Tags: South Asian, Type 1 Diabetes

Different Analysis of β-Cell Dysfunction as Fasting Glucose Progresses in Obese and Nonobese Newly Diagnosed Type 2 Diabetic Patients

October 28th 2019

During the progression of baseline FBG, β-cell dysfunction and insulin resistance worsened. As FBG increased, increased BMI had a positive influence on β-cell dysfunction in all FBG groups. The independent factors that correlated to EISI differed with the increasing of baseline FBG (Journal of Diabetes Research)

Categories: News, Pathology
Tags: beta cells, Insulin resistance, Type 2 Diabetes

Categories: Pathology
Tags: beta cells, Insulin resistance, Type 2 Diabetes

Characteristics of newly diagnosed adults with type 1 diabetes in the UK and evolution of glycaemic control, body mass index and Charlson comorbidity index over the first 5 years after diagnosis

October 27th 2019

More intensive support to reach and maintain glycaemic targets soon post-diagnosis, while avoiding weight gain, and prevention and optimal management of comorbidities are warranted (Primary Care Diabetes)

Categories: News, Pathology
Tags: Type 1 Diabetes

Categories: Pathology
Tags: Type 1 Diabetes

Variability in Glycated Hemoglobin and Risk of Poor Outcomes Among People With Type 2 Diabetes in a Large Primary Care Cohort Study

October 23rd 2019

HbA1c variability was strongly associated with overall mortality and emergency hospitalization and not explained by average HbA1c or hypoglycemic episodes. Only for CAD and IS hospitalizations was no association found, with average HbA1c strongly predictive. Targets should focus on both stability and absolute level of HbA1c (Diabetes Care)

Categories: News, Pathology
Tags: HbA1c, Type 2 Diabetes

Categories: Pathology
Tags: HbA1c, Type 2 Diabetes

Type 1 Diabetes is Associated with an Increase in Cholesterol Absorption Markers but a Decrease in Cholesterol Synthesis Markers in a Young Adult Population

September 30th 2019

Plasma markers suggest that cholesterol absorption is increased whereas cholesterol synthesis is decreased in type 1 diabetes. Further studies to address the impact of these changes on the relative efficacy of cholesterol absorption and synthesis inhibitors in subjects with type 1 diabetes are urgently needed (Journal of Clinical Lipidology)

Categories: News, Pathology
Tags: Lipidology

Categories: Pathology
Tags: Lipidology

HbA1c level as a risk factor for retinopathy and nephropathy in children and adults with type 1 diabetes: Swedish population based cohort study

August 29th 2019

Risk of retinopathy and nephropathy did not differ at HbA1c levels <6.5% but increased for severe hypoglycaemia compared with HbA1c levels 6.5-6.9%. The risk for severe complications mainly occurred at HbA1c levels >8.6%, but for milder complications was increased at HbA1c levels >7.0% (BMJ)

Categories: News, Pathology
Tags: HbA1c, Type 1 Diabetes

Categories: Pathology
Tags: HbA1c, Type 1 Diabetes

Longitudinal evaluation of gastric emptying in type 2 diabetes

August 16th 2019

In patients with long-term type 2 diabetes, gastric emptying of solids and liquids does not usually become more delayed over time, and abnormally slow gastric emptying of solids may improve (Diabetes Research and Clinical Practice)

Categories: News, Pathology
Tags: Gastroparesis, Type 2 Diabetes

Categories: Pathology
Tags: Gastroparesis, Type 2 Diabetes

Distinct trajectories of HbA1c in newly diagnosed Type 2 diabetes from the DPV registry using a longitudinal group‐based modelling approach

August 11th 2019

Four subgroups with distinct HbA1c trajectories were determined in newly diagnosed Type 2 diabetes using a group‐based modelling approach. Approximately one‐third of people with newly diagnosed Type 2 diabetes need either better medication adherence or earlier intensification of glucose‐lowering therapy (Diabetic Medicine)

Categories: News, Pathology
Tags: HbA1c, Type 2 Diabetes

Categories: Pathology
Tags: HbA1c, Type 2 Diabetes

The comorbidity burden of type 2 diabetes mellitus: patterns, clusters and predictions from a large English primary care cohort

July 30th 2019

Comorbidities are common in this population, and high between-patient variability in comorbidity patterns emphasises the need for patient-centred healthcare. Mental health is a growing concern, and there is a need for interventions that target both physical and mental health in this population (BMC Medicine)

Categories: News, Pathology
Tags: comorbidity, Type 2 Diabetes

Categories: Pathology
Tags: comorbidity, Type 2 Diabetes

Diabetes Mellitus Increases Risk of Gastric Cancer After Helicobacter pylori Eradication: A Territory-wide Study With Propensity Score Analysis

July 12th 2019

Type 2 DM is associated with an increased risk of GC among patients in whom HP was eradicated, in particular those with gastric cardia cancer and those with suboptimal DM control (Diabetes Care)

Categories: News, Pathology
Tags: cancer, Helicobacter pylori, Type 2 Diabetes

Categories: Pathology
Tags: cancer, Helicobacter pylori, Type 2 Diabetes

Longitudinal evaluation of gastric emptying in type 2 diabetes

June 23rd 2019

In patients with long-term type 2 diabetes, gastric emptying of solids and liquids does not usually become more delayed over time, and abnormally slow gastric emptying of solids may improve (Diabetes Research and Clinical Practice)

Categories: News, Pathology
Tags: gastric emptying, Type 2 Diabetes

Categories: Pathology
Tags: gastric emptying, Type 2 Diabetes

Discordance in risk factors for the progression of diabetic retinopathy and diabetic nephropathy in patients with type 2 diabetes mellitus

June 20th 2019

Average glycemia was significantly associated with progression of DR, whereas glycemic variability and dyslipidemia were significantly associated with progression of DN in type 2 diabetes mellitus (Journal of Diabetes Investigation)

Categories: News, Pathology
Tags: nephropathy, retinopathy, Type 2 Diabetes

Categories: Pathology
Tags: nephropathy, retinopathy, Type 2 Diabetes

Association between trabecular bone score and type 2 diabetes: a quantitative update of evidence

June 19th 2019

Patients with type 2 diabetes have a lower TBS than non-diabetic individuals, suggesting that TBS can be a useful measurement for the assessment of fracture risk in diabetic patients (Osteoporosis International)

Categories: News, Pathology
Tags: TBS, Type 2 Diabetes

Categories: Pathology
Tags: TBS, Type 2 Diabetes

Association between insulin resistance and haematological parameters: a cohort study from adolescence to adulthood

June 17th 2019

Both longitudinal and cross‐sectional analyses support the hypothesis that insulin resistance is associated with increased red blood cells count and haematocrit in young adults, even within normal ranges of insulin and glucose (Diabetes/Metabolism Research and Reviews)

Categories: News, Pathology
Tags: Insulin resistance

Categories: Pathology
Tags: Insulin resistance

Diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome: review of acute decompensated diabetes in adult patients

May 29th 2019

This review covers recommendations for acute management of diabetic ketoacidosis and HHS, the complications associated with these disorders, and methods for preventing recurrence. It also discusses why many patients who present with these disorders are at high risk for hospital readmissions, early morbidity, and mortality well beyond the acute presentation (BMJ)

Categories: News, Pathology
Tags: Diabetic Ketoacidosis, hyperglycemia

Categories: Pathology
Tags: Diabetic Ketoacidosis, hyperglycemia
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