The management of diabetes remains a substantial burden on children with diabetes and their families, despite improvements in treatment and rates of morbidity and mortality (The Lancet)
Diabetes News
Tag: Type 1 Diabetes
Type 1 Diabetes at a Crossroads!
What then are the major advances in type 1 diabetes? How close are we to realizing an intervention that can delay or prevent type 1 diabetes? Are we any closer to a cure today than we were 10 years ago? (Diabetes Care)
Glycated albumin and the risk of micro- and macrovascular complications in subjects with Type 1 Diabetes
Mean GA levels were more closely associated with DN progression than mean HbA1c in subjects with T1D. However, they were not associated with the CAA (Cardiovascular Diabetology)
Twice- rather than once-daily basal insulin is associated with better glycaemic control in Type 1 diabetes mellitus 12 months after skills-based structured education in insulin self-management
After structured education in adults with Type 1 diabetes mellitus, use of basal insulin twice rather than once daily was associated with lower HbA1c, independent of insulin type, with significant reductions in severe hypoglycaemia and ketoacidosis in all groups (Diabetic Medicine)
Role of the gastrointestinal ecosystem in the development of type 1 diabetes
This review examines the current knowledge of the role of the GI ecosystem in T1D and indicates the extensive opportunities for further investigation that could lead to biomarkers and therapeutic interventions for disease prevention and/or modulation (Pediatric Diabetes)
Intensive Diabetes Therapy and Ocular Surgery in Type 1 Diabetes
Intensive therapy in patients with type 1 diabetes was associated with a substantial reduction in the long-term risk of ocular surgery (New England Journal of Medicine)
The relationship between the frequency of self-monitoring of blood glucose and glycemic control in patients with type 1 diabetes mellitus on continuous subcutaneous insulin infusion or on multiple daily injections
An SMBG frequency of <3.5 times per day appeared to be a risk factor for poor glycemic control (HbA1c ≥8%) in type 1 diabetes mellitus patients on CSII (Journal of Diabetes Investigation)
Social Media and Diabetes
Can Facebook and Skype Improve Glucose Control in Patients With Type 1 Diabetes on Pump Therapy? One-Year Experience (Diabetes Care)
Reduction of hypoglycaemic events with a behavioural intervention: a randomized clinical trial for paediatric patients with Type 1 diabetes mellitus
Our findings suggest the need for a long-term (> 1 year) focus on the implementation of interventions targeting diabetes management in young people. Behavioural interventions targeting problem-solving skills could be considered as practical, non-pharmacological strategies to reduce hypoglycaemia in adolescents with Type 1 diabetes (Diabetic Medicine)
Glomerular haemodynamic profile of patients with Type 1 diabetes compared with healthy control subjects
Hyperfiltration in Type 1 diabetes is primarily driven by alterations in afferent arteriolar resistance rather than efferent arteriolar resistance. Renal protective therapies should focus on afferent renal arteriolar mechanisms through the use of pharmacological agents that target tubuloglomerular feedback, including sodium-glucose cotransporter 2 inhibitors and incretins (Diabetic Medicine)
Diabetes reversal via gene transfer: building on successes in animal models
The aim of this review is to evaluate the success of cell and gene therapy to reverse T1D in animal models for future clinical application (Dove Press)
Bariatric surgery and diabetes: Implications of type 1 versus insulin-requiring type 2
Our study suggests that improved glycemic control may not be an expected outcome when considering bariatric surgery in patients with DM1; however, additional investigation is warranted (Obesity)
Effect of Subcutaneous Insulin Detemir on Glucose Flux and Lipolysis during Hyperglycaemia in People with Type 1 Diabetes
The results are also consistent with the hypothesis that detemir has a lesser effect on the periphery, as evidenced by a lesser effect on peripheral glucose uptake at specific glucose concentrations (Diabetes, Obesity and Metabolism)
Insulin secretion in patients with latent autoimmune diabetes (LADA): half way between type 1 and type 2 diabetes: action LADA 9
The present study shows that the magnitude of stimulated insulin secretion in LADA is intermediate between that of type 1 and type 2 diabetes mellitus (BMC Endocrine Disorders)
Circulating dipeptidyl peptidase-4 activity is associated with insulin resistance in type 1 diabetic patients
Serum DPP4 activity is associated with IR in T1DM patients and it might play an important role in its pathophysiology (Diabetes and Its Complications)
Cardiac Autonomic Dysfunction Is Associated With High-Risk Albumin-to-Creatinine Ratio in Young Adolescents With Type 1 Diabetes in AdDIT (Adolescent Type 1 Diabetes Cardio-Renal Interventional Trial)
Adolescents at potentially higher risk for nephropathy show an adverse cardiac autonomic profile, indicating sympathetic overdrive, compared with the lower-risk group. Longitudinal follow-up of this cohort will further characterize the relationship between autonomic and renal dysfunction and the effect of interventions in this population (Diabetes Care)
Plasma Levels of MASP-1 and MASP-2 are Elevated in Type 1 Diabetes and Correlate with Glycaemic Control
MASP-1 and MASP-2 levels were significantly higher in children and adults with T1DM than in their respective control groups (Clinical and Experimental Immunology)
Corneal Confocal Microscopy Predicts 4-Year Incident Peripheral Neuropathy in Type 1 Diabetes
DPN can be predicted by various demographic, metabolic, and conventional neuropathy measures. The ability of CCM to predict DPN broadens the already impressive diagnostic capabilities of this novel ophthalmic marker (Diabetes Care)
NICE guideline consultations
Glycaemic control of Type 1 diabetes in clinical practice early in the 21st century: an international comparison
These results suggest that there are substantial variations in glycaemic control among people with Type 1 diabetes between the data sources and that there is room for improvement in all populations, especially in young adults (Diabetic Medicine)
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