Our study identified that baseline HbA1c acted as the sole predictor of exenatide response and that response may be determined after 3 months of exenatide administration (Journal of Diabetes Research)
Diabetes News
Tag: Type 2 Diabetes
Evidence-base on type 2 diabetes mellitus
This document summarises the evidence-base on type 2 diabetes mellitus. It is a key therapeutic topic which has been identified to support Medicines Optimisation. It is not formal NICE guidance (NICE)
Insulin secretion in patients with latent autoimmune diabetes (LADA): half way between type 1 and type 2 diabetes: action LADA 9
The present study shows that the magnitude of stimulated insulin secretion in LADA is intermediate between that of type 1 and type 2 diabetes mellitus (BMC Endocrine Disorders)
Remission of Type 2 Diabetes After Roux-en-Y Gastric Bypass or Sleeve Gastrectomy Is Associated With a Distinct Glycemic Profile
Remission of T2DM after RYGBP and SG is associated with distinct glycemic profiles. However, longer time spent in hyperglycemia and in hypoglycemia after RYGBP compared with SG is not associated with persistence of altered beta cell function or higher rates of relapse of T2DM over time (Annals of Surgery)
Insulin Cessation and Diabetes Remission After Bariatric Surgery in Insulin-Treated Type 2 Diabetic Adults
Insulin-treated type 2 diabetes patients have a greater probability of stopping insulin after RYGB than after LAGB (62% vs. 34%, respectively, at 1 year), with weight-independent effects in the early months after surgery. These findings support RYGB as the procedure of choice for reversing I-T2D (Diabetes Care)
Glycemic Variability Is Associated With Reduced Cardiac Autonomic Modulation in Women With Type 2 Diabetes
In patients with newly diagnosed and well-controlled type 2 diabetes, increased glycemic variability was associated with reduced cardiac autonomic modulation in women but not in men (Diabetes Care)
Insulin Cessation and Diabetes Remission After Bariatric Surgery in Insulin-Treated Type 2 Diabetic Adults
Insulin-treated type 2 diabetes patients have a greater probability of stopping insulin after RYGB than after LAGB (62% vs. 34%, respectively, at 1 year), with weight-independent effects in the early months after surgery (Diabetes Care)
NICE guideline consultations
Allopurinol treatment improves renal function in patients with type 2 diabetes and asymptomatic hyperuricemia: 3-year randomized parallel-controlled study
Long-term effective control of serum uric acid can decrease UAER and serum creatinine, increase GFR and may exert kidney protection effects in patients with type 2 diabetes and asymptomatic hyperuricemia (Clinical Endocrinology)
Management of Hyperglycemia in Type 2 Diabetes, 2015
A Patient-Centered Approach: Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes (Diabetes Care)
Type 2 diabetes and cancer: umbrella review of meta-analyses of observational studies
Though type 2 diabetes has been extensively studied in relation to risk of developing cancer and cancer mortality and strong claims of significance exist for most of the studied associations, only a minority of these associations have robust supporting evidence without hints of bias (BMJ)
Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients
Disordered early phase insulin and glucagon secretions but not incretin secretion are involved in hyperglycemia after ingestion of nutrients in T2DM of even a short duration (Journal of Diabetes and Its Complications)
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